You can toggle the open, click, and sync to Live Feed tracking settings on a per-Sequence basis as well, in the following way:
Navigate to the Settings tab in any sequence.
Go to the horizontal Tracking tab at the Settings page of your sequence, and check the boxes next to Track opens, Track clicks, and Sync to Mixmax as required.
If you choose not to track opens, you cannot send follow-up stages with the 'If not read' trigger. You can still send a sequence with follow-up stages 'If not replied' and 'Regardless'.